The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study

| July 2013 | 625 study on rat model of CP nephrotoxicity and observed, losartan may prevent CIN in males, but it promotes the CP‐induced damage in females, which may be related to the renin‐angiotensin system receptors in the kidneys.[7] Additionally, we recently reported that, vitamin E, vitamin C, or losartan is not nephroprotectant against CIN in presence of estrogen in ovariectomized rat model,[8] which is in agreement with our previous findings. More recently we observed that estrogen abolished protective effect of erythropoietin against CIN in ovariectomized rats,[9] while renoprotective effects of erythropoietin was also shown in our previous study.[10‐13] Hence, it is well documented that there is a gender difference in the CIN in the rat model. It is documented that some cases of chronic renal diseases are gender related too.[13‐19] Few studies published regarding the sex difference in CIN.[19,20] Hence, there still remains a number of big questions to further explore mechanisms interact in CIN. We propose to conduct clinical studies to understand the factor of gender difference in CIN.